two groups of patients with general condition and population statistical data
已有 121 次阅读 2013-04-21 01:28 标签: Pendentifs Tiffany pas cher1997, the United States Food and Drug Administration (FDA) approved the intra-articular injection of hyaluronic acid for the treatment of osteoarthritis of the knee. Although the FDA hasn't approved the hyaluronic acid for ankle vestito da sposa, but many studies have shown that hyaluronic acid has significant therapeutic effect on osteoarthritis of ankle joint, safe and reliable. Generally speaking camicie Paul Smith uomo, hyaluronic acid injection to articular cavity one Monday time, continued for 3-5 weeks. And there are studies that show high molecular weight cross-linked hyaluronic acid single dose can significantly relieve the knee and ankle pain. Single-dose can indeed reduce the equipment, operation and other related adverse events. But at present in the treatment of ankle osteoarthritis, sodium hyaluronate dosing frequency, drug combination is the best model to select is not clear. In order to verify the low molecular weight non cross-linked hyaluronic acid single intra-articular injection effect, from the United States Henry costume Pietro Santo homme; of Massachusetts; DeGroot professor III case-control study was performed in a prospective randomized double blind placebo, published in January 4, 2012 by JBJS (Am) magazine. The
researchers in the local newspaper, broadcast, research institutions website platform advertising to recruit volunteers, refer to table 1 inclusion and exclusion criteria, a total of 64 patients with ankle osteoarthritis enrolled in this study, 39 cases in treatment group, 25 cases in the control group, two groups of patients with general condition and population statistical data, see table 2.
treatment of intra-articular injection of sodium hyaluronate (2.5ml Supartz camicia La Martina; Seikagaku, Tokyo, Japan), as the non-crosslinked, molecular weight of 620000 to 1170000 Da, 2.5ml containing hyaluronic acid 25mg. The control group was given normal saline 2.5ml. Before treatment, after 6 weeks, 12 weeks respectively record the United States Association of foot and ankle surgery physicians (AOFAS) clinical grading, and takes it as the main evaluation index; secondary endpoints included osteoarthritis of ankle joint registration score (AOS) and visual analogue scale (VAS), ratio of each parameter changes before and after treatment the. Table 1
inclusion and exclusion criteria
Table 2 after randomization baseline data
artificial statistics data and function of two groups pain score of 1 flow chart of the study. ITT: Intention Study; AE: adverse events.
finally 56 patients completed the study, 8 patients dropped out. 1 cases of adverse events (1.6%), 1 patients in the treatment group injection of hyaluronic acid after ipsilateral inguinal lymph nodes scarpe Timberland uomo, without special treatment, subside. The average AOFAS score in treatment group after treatment for 6 weeks and 12 weeks were higher than in the previous stage of improvement of 4.9 points; while the control group respectively improved 0.4 and 5.4. Both the treatment group and the control group were significantly improved after treatment, but the degree of improvement of the two groups had no significant difference (P=0.196; 0.897). AOS, VAS were also found similar results. The treatment group AOS improvement at 6 weeks and 12 weeks respectively 5 and 5.3 points, the control group was 8.4 and 14.8, the difference between the degree of improvement group had no statistical significance (P=0.577; 0.138). The VAS of the treatment group was 6 and 12 weeks respectively improved 6.4 and 4.1 points Porte verre pas cher, respectively improved 3 and 11.1 in control group, the difference between groups have no statistical significance (P=0.632; 0.309).
results from the research perspective, for osteoarthritis of ankle joint, a single intra-articular injection of low molecular weight non cross-linked hyaluronic acid effect compared with saline and there is no obvious advantage.
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